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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: J Cereb Blood Flow Metab. 2009 May 6;29(7):1229–1239. doi: 10.1038/jcbfm.2009.48

Figure 6. CNS-Resident Macrophages express MHC-II complex and TNF-α.

Figure 6

Immunohistochemistry (Set A, contiguous sections): ED-2+ and PB+ macrophages (arrows) were identified within the meninges, choroid plexus, and perivascular locations [colocalized images, 20×, scale bar = 25 µm]. Brown = ED-2+, Blue = PB+, Background = nuclear fast red counterstain. Immunofluorescence (Set B, contiguous sections): These ED-2+ and PB+ macrophages, located at the interface between the blood-brain barrier and the extravascular space, were found to express both MHC-II complex and TNF-α [colocalized images, 40×, scale bar = 25µm]. Blue = DAPI for nuclei. Red = Rhodamine for ED-2/MHC-II. Green = FITC for TNF-α.