Table 1.
Signaling pathways for NO, H2S, and CO in the vasculature. ACh, acetylcholine; SMC, smooth muscle cell.
| Vasculature | NO | H2S | CO |
|---|---|---|---|
| Synthetic enzymes | eNOS | CSE | HO2 |
| Endothelial localization | Yes | Yes | Yes |
| Activation signal | ACh | ACh | ACh |
| Ca2+-CaM regulation | Yes | Yes | Yes |
| Downstream target(s) | sGC-cGMP* | K+ channel (KATP)? | sGC-cGMP |
| Target location | SMC | SMC | SMC |
| Chemical modification (Cys) | S-nitrosylation? | S-sulfhydration | ? |
| Vasorelaxation | Yes | Yes | Yes |
| KO phenotype | Hypertension | Hypertension | ? |
| Concentration (μM) | <0.2 | 40−150 | ? |
*
NO has various other targets in vascular smooth muscle in addition to sGC.