Table 3.
Selected physiologic targets of NO, H2S, and CO.
| Selected protein targets | NO | H2S | CO | References |
|---|---|---|---|---|
| Dexras1 | ↑ Activity | (14) | ||
| HIF1α | ↑ Stability/Activity | ↑ Stability/Activity | (20, 61) | |
| Arginase | ↑ Activity | (40) | ||
| Serine racemase | ↓ Activity | (42) | ||
| NSF | ↑ Activity | (43, 44) | ||
| ↓ Exocytosis of Weibel-Palade bodies | ||||
| ↑ Surface AMPA receptor | ||||
| GRK2 | ↓ Activity | (45) | ||
| β-Arrestin 2 | ↑ β-Adrenergic receptor endocytosis | (46) | ||
| RyR1 | ↑ Temperature sensitivity | (47, 48) | ||
| TRP channels | ↑ Activity | (49) | ||
| MAP1B | ↑ Binding to microtubule | (50) | ||
| ↑ Neurite retraction | ||||
| PDI | ↓ Activity | (51) | ||
| Parkin | ↓ Activity | (52) | ||
| COX2 | ↑ Activity | (53, 58) | ||
| GAPDH | ↓ Activity | ↑ Activity | (54, 55, 72) | |
| Nuclear translocation | ||||
| Ras | ↑ Activity | (56) | ||
| MMP-9 | ↑ Activity | (57) | ||
| CREB | ↑ DNA binding | (62) | ||
| HDAC2 | ↑ Chromatin remodeling | (63) | ||
| E75 | ↓ Activity | (68) | ||
| NPAS2 | ↑ Activity | (69) | ||
| KATP | ↑ Activity | (71) |