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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Cell Cycle. 2008 Mar 10;7(9):1197–1204. doi: 10.4161/cc.7.9.5886

Figure 1.

Figure 1

Increased mortality and body weight loss of Clock/Clock female mice after low-dose irradiation. (A) Kaplan-Meyer survival curve (mean survival for WT and Clock/Clock mice are 73.2 and 63.6 weeks respectively, p = 0.022). Solid line—WT mice, dotted line—Clock/Clock mice. All survived animals were sacrificed 80 weeks post irradiation (B) Changes in body weight of WT and Clock mutant mice; t = 0 corresponds to the time of irradiation. Fifteen WT and fifteen Clock/Clock mice were weighed weekly. Starting at 20 weeks after irradiation Clock mutant mice demonstrate progressive weight loss (p < 0.001). Data shown as mean ± s.e.m. Closed circles—WT; open circles—Clock/Clock. (C) Gross appearance of WT (right) and Clock/Clock (left) female mice 80 weeks after TBI. Note significant reduction in weight, kyphosis and cataract in Clock mutant female. (D) Weight of major organs from female mice after 80 weeks of TBI (mean ± s.e.m.; *p < 0.01; filled bars—WT, open bars—Clock mutant mice. Liver, spleen and kidney of Clock/Clock female mice showed significant reduction when compared to age-matched WT mice.