Table 1.
Histopathological evaluation of wild-type (WT) and clock/clock female mice
| WT (lesion/total) | Clock/clock (lesion/total) | Fisher’s exact test p (*significant) | |
|---|---|---|---|
| Spleen | |||
| Splenomegaly (>200 mg) | 10/13 | 1/12 | 0.0010* |
| Hyperplasia of the white pulp | 2/12 | 4/12 | 0.6404 |
| Follicular lymphoma | 2/12 | 1/12 | 1.0000 |
| Extramedullary hematopoiesis | 10/12 | 4/12 | 0.0361* |
| Hemangioma | 1/12 | 1/12 | 1.5217 |
| Mandibular lymph nodes | |||
| Visually enlarged | 1/13 | 9/12 | 0.0010* |
| Hyperplasia/medullary plasmacytosis | 4/12 | 9/11 | 0.0361* |
| Angiectasis | 6/12 | 1/11 | 0.0686 |
| Other lesions: | |||
| Liver, ductal cystadenoma | 2/13 | 2/12 | 1.0000 |
| Liver, hemangioma | 0/13 | 1/12 | 0.4800 |
| Liver, hepatocellular adenoma | 1/13 | 0/12 | 1.0000 |
| Ovary, cystadenoma | 1/13 | 1/12 | 1.0000 |
| Ovary, granulosa cell tumor | 0/13 | 1/12 | 0.4800 |
| Salivary gland, ductal cystadenoma | 2/13 | 1/12 | 1.0000 |