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. 2009 Sep 23;4(9):e7139. doi: 10.1371/journal.pone.0007139

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Koehler et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Four-color flow cytometry showing T cell dynamics for (A) CD4+ T cells (CD3+CD20−CD4+CD8−), (B) CD8+ T cells (CD3+CD20−CD4−CD8+), and (C) CD4+/CD8+ T cell ratios. In this and subsequent figures, results from animals were averaged through day 318. The downward arrow indicates time of SIV inoculation (day 86). Parasitemias are indicated on the x-axis by a green x (malaria-only) or an open purple triangle (SIV/malaria). SIV-only animals were sampled starting at SIV infection, and the malaria-only animals were sampled until the group stopped relapsing. Results for individual animals throughout the course of infection are shown in Figure S1.