Fig. 1.

Effects of ethanol on foreground contextual fear conditioning at 4 and 24 hours post-training. Ethanol or saline was administered 15 minutes before training. Groups administered 0.25 g/kg ethanol froze to the context significantly more than controls, while groups administered 1.0 g/kg ethanol froze significantly less than controls. In addition, the enhancement by the 0.25 g/kg dose of ethanol was significantly greater at 24 hours compared with 4 hours. The groups administered 0.5 g/kg ethanol were not significantly different from controls. The absence of significant differences in freezing to an altered context (pre-conditioned stimulus; pre-CS) or to a tone (CS) was expected because mice were not trained to an auditory CS (mean ± SEM; *indicates significant difference from controls, p < 0.05; #indicates significant difference, p < 0.05).