TABLE 1.
Modifiers of Hepatic Fibrosis Using Knock Out Mice
| Increased “Protective”∗ | Decreased “Fibrogenic”∗∗ |
|---|---|
| IL-6, IL-10 | TNFR1, TLR4, CD14 |
| iNOS | Angiotensin R1a |
| Plasminogen | NADPH oxidase |
| Interferon γ | TGFβ1, Smad3, MMP13 |
| Adiponectin | P21 |
| Telomerase | FGF1/2, FGFR4 |
| Bcl-xL | Leptin, OB-R |
| SOCS1 (+/−) | Dopamine βhydroxylase |
| Keratin | FasL, Cathepsin B |
| C5 |
∗ Increased “Protective” - means the knock out mice have increased fibrosis and, therefore, the gene is protected from fibrosis
∗∗ Decreased “Fibrogenic” - means the knock out mice have decreased fibrosis and, therefore, the gene is fibrogenic