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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Clin Exp Allergy. 2009 Apr 7;39(6):798–806. doi: 10.1111/j.1365-2222.2009.03241.x

Figure 3. OX40L and IL-25 (IL-17E) maintain chronic allergic responses.

Figure 3

DCs activated by TSLP can expand and activate resident Th2 memory cells that upregulates the expression of proallergic molecules, including IL-25R, cystatin A, Charcot-Leydon crystal protein, and prostaglandin D2 synthase. During chronic allergic inflammation, infiltrated mast cells, eosinophils, basophils, and injured structural cells can produce IL-25 that can further enhance TH2 cytokines production, in particular IL-5 and IL-13 by DC-activated TH2 memory cells.

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