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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Free Radic Biol Med. 2008 Aug 8;45(9):1290–1301. doi: 10.1016/j.freeradbiomed.2008.08.002

Fig. 2.

Fig. 2

Generation of dynamic model of α-syn toxicity (A and B are in silico data). (A) Dose-dependent effect of PI (2.5 μM) in silico on cell viability (with 8-OHdG levels as marker of apoptosis) in cells expressing either WT (W) or A53T α-syn (M) compared to control (C). (B) Percentage DNA damage without and with PI (2.5 μM) in control, WT, and A53T α-syn cells measured by the amount of 8-OHdG, a biomarker for DNA damage and apoptosis.