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. Author manuscript; available in PMC: 2010 Jan 30.
Published in final edited form as: Nature. 2009 Jul 30;460(7255):632–636. doi: 10.1038/nature08177

Figure 3. Presynaptic PS regulates glutamate release via intracellular Ca2+ stores.

Figure 3

a. Reduced decay rate of NMDAR-mediated responses in the presence of MK-801 in CA3-PS cDKO mice. b. Amplitude of the first NMDAR-mediated response (left) and decay time constant (fitted to a single exponential curve) of the NMDAR-mediated EPSC slope in the presence of MK-801 (right). Representative traces of EPSCs after the 1st, 10th and 50th stimulus are shown in the inset. c. Effects of thapsigargin treatment on synaptic facilitation in control and CA3-PS cDKO slices. All data represent mean ± s.e.m. *p < 0.05; **p < 0.01. The number of slices or neurons (left) and mice (right) used in each experiment is indicated in parenthesis.