A, B, Diagnostic performance by histology: MFI values of mesothelin A, and HE4 B, as measured by Bb/pAb assays; controls (1) and (2−6) ovarian cancers (gray circles, early stages; crosses, late stages): type clear cell (2), serous (3), mucinous (4), endometrioid (5) and others (6). C, Composite marker (CM) =1.12(HE4) + 0.45(mesothelin). Weight for HE4=0.71. Weight for mesothelin=0.29.