Table 1.

Mean relative luciferase units per million Plasmodium falciparum parasites (RPM) and related statistics obtained from independent assays of parasite lines containing the integrated luciferase cassettes.

Parasite linea	Mean RPM (n)	S.D.	Skewnessb	Kurtosisc	Geo. Meand	95% CI of Geo. Mean	P valuee
ALH	4.7 (9)	5.86	0.865	-0.972	2.07	0.687, 6.213	n/a
ALHi	3.8 (9)	9.13	2.044	2.548	0.44	0.069, 2.831	<0.05
ALA1	0.2 (9)	0.17	0.387	-1.566	0.13	0.055, 0.311	<0.01
ALA2	0.3 (9)	0.36	1.603	1.281	0.17	0.070, 0.401	<0.001
∂LH	0.003 (4)	0.005	0.749	-1.688	0.00004	3 × 10-8, 4 × 10-5	0.0145
HLH	6601 (5)	5086	0.323	-1.819	4917	1591, 15196	n/a
HLHi	7636 (5)	8298	0.52	-1.726	3993	720.5, 22133	ns
HLA	1791 (5)	2036	0.413	-1.975	802.3	112.7, 5713	<0.01

^aAll lines were derived from the P. falciparum Dd2^attB strain.

^bSkewness describes the asymmetry of the distribution. Positive values have distributions asymmetrically skewed to the right (higher values), negative values are skewed to the left (lower values).

^cKurtosis quantifies the shape of the distribution as Gaussian or non-Gaussian. Gaussian distributions have 0 kurtosis, distributions with more values in the center have negative kurtosis, and those with more values in the tails have positive kurtosis.

^dThe geometric mean is the antilog of the mean of the log-transformed values, which allows comparison of the transformed mean values in the original units. The variance of the geometric mean is captured by the 95% confidence interval (CI).

^eP values were calculated using repeated measures ANOVA such that the UpsA promoter lines constituted one group (P value= 0.003) and the hrp3 promoter lines constituted a second group (P value= 0.0056). The Dunnett’s post-test was used for between-line comparisons. The P value for the ∂LH line was derived from a paired t test using matched ALH values. n/a, not applicable.