TABLE 2.

Whole blood cytokine production in response to 24-h LPS treatment at baseline in elderly nursing home residents by cytokine genotype group¹

Cytokine	Genotype	n	LPS, 1.0 mg/L	LPS, 0.01 mg/L
TNFα	TNFα -308G > A2		ng/L
	G/G	71	1127 ± 1013	358 ± 390a,b
	A/G	21	2060 ± 2463	615 ± 694b
	A/A	6	1008 ± 1161	269 ± 338a
	P3		0.10	0.03
IL-6	IL-6–174C > G
	C/C	43	9571 ± 5564	5758 ± 3336
	G/C	42	9082 ± 5608	5836 ± 3574
	G/G	15	7195 ± 3751	4356 ± 1827
	P		0.24	0.18
IL-1β	IL-1β -1473G > C
	G/G	59	568 ± 367	286 ± 217
	C/G	38	514 ± 284	284 ± 196
	C/C	2	769 ± 760	333 ± 303
	P		0.73	0.94
	IL-1β -511G > A
	G/G	45	597 ± 387	292 ± 224
	A/G	48	514 ± 279	286 ± 194
	A/A	6	511 ± 476	253 ± 233
	P		0.25	0.25
	IL-1β 3954G > A
	G/G	63	540 ± 367	271 ± 203
	A/G	33	574 ± 282	316 ± 212
	A/A	3	550 ± 562	287 ± 316
	P		0.55	0.46
	IL-1β 6054G > A
	G/G	37	533 ± 324	275 ± 190
	A/G	44	509 ± 266	273 ± 192
	A/A	18	694 ± 501	342 ± 276
	P		0.37	0.77

¹Data are unadjusted means ± SD. Means in a column with superscripts without a common letter differ, P < 0.05. (Tukey's post hoc test). The effect of genotype was assessed using ANOVA on log-transformed data. P-values are unadjusted.

²The number of observations at baseline for TNFα stimulated with 0.01 mg/L of LPS was G/G n = 62, A/G n = 20, A/A n = 5. All other SNP had equal numbers in each stimulation condition.