Table 1.

Effect of zonulin on mouse gastroduodenal (sucrose) and small intestinal (lacman) permeability in vivo

Treatment	Challenge		Recovery After 48 h
	Change in sucrose, %	Change in lacman, %	Change in sucrose, %	Change in lacman, %
Zonulin	68.44 ± 17.52*	22.91 ± 5.4†	1.33 ± 3.59	0.94 ± 2.19
2-Chain HP2	8.75 ± 6.67	0.09 ± 4.40	0.60 ± 6.14	0.48 ± 1.78
BSA	−0.40 ± 2.91	0.03 ± 1.54	—	—

*Sucrose P = 0.0049 compared with both BSA control and 2-chain HP2 (n = 10 for each group of treatment).

^†Lacman P = 0.0024 compared with both BSA control and 2-chain HP2.