Fig. 6.

Global effects on genes interrogated by using Affymetrix high-density Human Genome U133 Plus 2.0 arrays. (A) Agglomerative clustering of transcripts induced or repressed by dexamethasone (dex) by at least 2-fold under the 4 specified conditions: no treatment control, mifepristone (mif, 3 μM), polyamide 1 (5 μM), and polyamide 2 (5 μM). Clustering was based on an error-weighted Euclidean correlation of intensity ratios for each treatment as compared with dex-induced controls. (B) Venn diagram representing genes affected ( fold change >2.0, P < 0.01) by dex and mif. (C) Venn diagram representing genes affected ( fold change > 2.0, P < 0.01) by dex and mif as well as by dex and polyamide 1. Numbers inside the intersections represent genes affected by both treatments.