Table 1.
Genes affected >2-fold by dexamethasone and mifepristone whose activity is modulated by polyamide 1 and not by polyamide 2*
| Gene | Fold induction | Gene | Fold induction | Gene | Fold induction | Gene | Fold repression |
|---|---|---|---|---|---|---|---|
| CDKN1C (N33167) | 20 | IGFBP1 (NM_000596) | 4 | 49111_at (N80935) | 3 | NR4A2 (NM_006186) | 6 |
| FKBP5 (NM_004117) | 14 | CDC42EP3 (AI754416) | 4 | TIPARP (AL556438) | 3 | IER2 (NM_004907) | 3 |
| DNAJC15 (NM_013238) | 14 | PLEKHA7 (AA758861) | 4 | EPB41L4A (AU144565) | 3 | EREG (NM_001432) | 3 |
| FGD4 (AI949549) | 11 | CEP3 (AI801777) | 4 | CEBPD (NM_005195) | 3 | IER3 (NM_003897) | 3 |
| CIDEC (NM_022094) | 8 | LOC153346 (AU157049) | 4 | EMP1 (NM_001423) | 3 | NR0B1 (NM_000475) | 3 |
| EDN3 (NM_000114) | 8 | IL6R (NM_000565) | 4 | LOC54492 (AK026748) | 3 | MAFK (BG231691) | 3 |
| PTGER4 (AA897516) | 8 | ARRB1 (BE207758) | 4 | ARRB1 (BC003636) | 3 | CYP24A1 (NM_000782) | 3 |
| METTL7A (NM_014033) | 7 | CDC42EP3 (AL136842) | 4 | SOCS1 (AB005043) | 3 | EDN1 (NM_001955) | 2 |
| FAM105A (NM_019018) | 7 | AKAP13 (NM_006738) | 3 | SCNN1G (AI985987) | 3 | NEIL3 (NM_018248) | 2 |
| ATAD4 (NM_024320) | 6 | 244650_at (AA581439) | 3 | EPB41L4B (NM_019114) | 3 | PTGS2 (AY151286) | 2 |
| GOLSYN (NM_017786) | 6 | PKP2 (NM_004572) | 3 | ARRB1 (NM_004041) | 3 | RND1 (U69563) | 2 |
| CORO2A (AL515381) | 5 | FBXL16 (AI613010) | 3 | IL6R (NM_000565) | 3 | ||
| TFCP2L1 (NM_014553) | 5 | CEBPD (AV655640) | 3 | MT1F (BF246115) | 2 | ||
| RASSF4 (N49935) | 5 | FOXO3 (AV725666) | 3 | JPH2 (AA716165) | 2 | ||
| CDH16 (NM_004062) | 4 | FLVCR2 (NM_017791) | 3 | SLC22A5 (NM_003060) | 2 | ||
| ACSL1 (NM_021122) | 4 | MT2A (NM_005953) | 3 | RHOU (AL096776) | 2 | ||
| MT1X (NM_002450) | 4 | KIAA0146 (AI363213) | 3 | MAN1C1 (NM_020379) | 2 | ||
| AKAP13 (NM_006738) | 4 | 43511_s_at (AI201594) | 3 | KIAA0232 (D86985) | 2 | ||
| ACSL1 (NM_001995 | 4 | ETNK2 (NM_018208 | 3 |
*These genes may represent glucocorticoid-responsive genes that are controlled via direct GR-binding mechanisms.