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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2009 Aug 3;15(10):1239–1243. doi: 10.1016/j.bbmt.2009.06.009

Fig. 2. Potential strategies for manipulation of Treg cells following IAC or antigen induced activation by targeting up-regulated cell surface molecules.

Fig. 2

Treg cells can be activated and expanded following experimental treatment with IAC (IL2 / anti-IL2 complex) or via responsiveness to auto (self), allogeneic (transplant) or conventional (pathogen) antigen. Following activation, up-regulation of cell surface molecules including CD25 and TNFR family members may provide ‘targets’ for additional manipulation of different Treg populations. 4-1BB (TNFRS9), Ox-40 (TNFRS4) and GITR (TNFRS18) reported to affect Treg function are shown, but other TNF family molecules as well as molecules yet to be identified could become potential targets for manipulation.