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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Jul 14;1793(10):1604–1613. doi: 10.1016/j.bbamcr.2009.07.001

Fig. 6. NRF-1 over-expression in primary neurons significantly increased mRNA levels for Nos1, COX2, and COX6c genes and rescued them from TTX-induced suppression.

Fig. 6

NRF-1, Nos1, COX2, COX6c, Nos2, and Nos3 mRNA levels (A–F) were all reduced by TTX as compared to controls. Over-expression of NRF-1 significantly increased transcript levels of NRF-1, Nos1, COX2, and COX6c, but not of Nos2 and Nos3. Over-expression of NRF-1 was able to rescue NRF-1, Nos1, COX2, and COX6c, but not Nos2 and Nos3. Group means were analyzed for overall statistical significance using the Student's t-test (N = 6 for each group). All * P values were compared to empty vectors (* P < 0.05, ** P < 0.01, *** P < 0.001). All # P values were compared to empty vector + TTX (# P < 0.05, ## P < 0.01, ### P < 0.001), and all X P values were compared to NRF-1 over-expression (X P < 0.05, XXX P < 0.001).