Table 3.

Efficacy results measured as sustained and point prevalence reductions in smoking and point prevalence abstinence rates according to treatment with oral nicotine inhaler (active treatment) or placebo

Definition	Time point (months)	No (%) with active treatment	No (%) with placebo	Odds ratio (95% CI)	P value (Fisher's test)
Sustained
Reduction*	4	52 (26.0)	18 (9.0)	3.55 (2.04 to 6.19)	<0.001
	12	26 (13.0)	8 (4.0)	3.59 (1.65 to 7.80)	0.002
	24	19 (9.5)	6 (3.0)	3.39 (1.39 to 8.29)	0.012
Point prevalence
Reduction†	4	83 (41.5)	44 (22.0)	2.52 (1.63 to 3.87)	<0.001
	12	59 (29.5)	43 (21.5)	1.53 (0.97 to 2.40)	0.085
	24	55 (27.5)	46 (23.0)	1.27 (0.81 to 2.00)	0.357
Abstinence‡	4	13 (6.5)	4 (2.0)	3.41 (1.16 to 10.01)	0.044
	12	16 (8.0)	12 (6.0)	1.36 (0.63 to 2.95)	0.557
	24	21 (10.5)	17 (8.5)	1.26 (0.65 to 2.47)	0.609

^*Sustained reduction in number of cigarettes smoked daily by at least 50% from week 6, verified by decreased carbon monoxide concentrations compared with baseline. 

^†Point prevalence reduction of cigarettes smoked daily by at least 50% at months 4, 12, and 24, verified by decreased carbon monoxide concentrations compared with baseline. 

^‡No cigarettes smoked, verified by carbon monoxide concentrations <10 ppm at months 4, 12, and 24.