Table 1.

Table 1 ADE Surveillance Rules

Rule Description
Amikacin > 35 Post
Anti-Xa laboratory test result > 2
Carbamazepine > 14
Clostridium difficile infection
Digoxin > 2.5
Flumazenil administered
Gentamicin > 40 and cystic fibrosis; gentamicin > 15 all other patients
Gentamicin trough > 3
Hepatotoxicity: elevated liver function test (2.5x ULN)
Hyperkalemia: potassium > 6.5 and age > 1 yr
Hyperphosphatemia: phosphorus > upper limit of normal
Hypocalcemia: calcium < 8.6 with drug cause
Hypoglycemia: glucose < 40 and insulin
Hypokalemia: potassium < 3
Hypomagnesemia: Mg2+ < 1.6
Hyponatremia: sodium < 135 with drug cause
Hypophosphatemia: phosphorus < lower limit of normal
INR > 4.5
Metabolic acidosis: anion gap > 11 with drug cause
Naloxone administered
Nephrotoxicity: (Scr 2× increase over past 2 days) or (Scientific Review > 1.5x ULN)
Neutropenia: ANC < lower limit of normal
Pancreatitis: elevated pancreatic enzymes (1.5x ULN)
Phenobarbital > 50
Phenytoin > 18 and <= 20 and albumin < 3.3
Phenytoin > 20
Seizures (as indicated by admin. Of lorazepam or diazepam)
Tacrolimus > 20
Thrombocytopenia (HIT): platelets > 100,000 with 50% decline from baseline
Tobramycin > 40 and cystic fibrosis; tobramycin > 15 all other patients
Tobramycin trough > 3
Vancomycin trough elevated > 25

ADE = adverse drug event; INR = international normalized ratio; ULN = upper limit of normal.