Fig. 1.

Transverse T2-weighted images (3,000/22, 60 and 120, one excitation) in two patients. MRIs at ages 3 (a) and 6 years (b) in patient 1 showed symmetric signal abnormalities in the cerebral white matter, with mild swelling and a frontal predominance. The white matter abnormalities showed only minor increase on follow-up. In patient 3, two MRI studies at age 8 (c) and 10 years (d) showed little change in the bilateral frontal white matter abnormalities with swelling