Table 4.
Loci controlling skin lesion development after infection with L. major in both sexes and separately in female and male F2 hybrids between CcS-11 and BALB/c
| Locus | Group | Marker | Genotype | P value | Corrected P value | ||
|---|---|---|---|---|---|---|---|
| CC | CS | SS | |||||
| Lmr5 | Both sexes | D10Mit12 | 79.09 ± 1.61 (n = 62) | 71.46 ± 1.03 (n = 151) | 59.18 ± 1.40 (n = 82) | 1.16 × 10−6 | 5.27 × 10−5 |
| D10Mit46 | 79.84 ± 1.64 (n = 61) | 70.94 ± 1.04 (n = 151) | 58.90 ± 1.47 (n = 76) | 1.05 × 10−6 | 4.83 × 10−5 | ||
| Females | D10Mit12 | 79.06 ± 2.29 (n = 33) | 66.16 ± 1.58 (n = 70) | 52.01 ± 1.91 (n = 48) | 6.34 × 10−6 | 2.67 × 10−4 | |
| D10Mit46 | 79.19 ± 2.52 (n = 28) | 66.60 ± 1.56 (n = 73) | 52.26 ± 1.91 (n = 49) | 1.88 × 10−5 | 7.28 × 10−4 | ||
| Males | D10Mit12 | 79.12 ± 2.15 (n = 29) | 76.03 ± 1.29 (n = 81) | 69.23 ± 1.98 (n = 34) | 0.147 | NS | |
| D10Mit46 | 80.39 ± 2.03 (n = 33) | 75.00 ± 1.32 (n = 78) | 70.89 ± 2.24 (n = 27) | 0.207 | NS | ||
| Lmr21 | Both sexes | D7Mit282 | 109.53 ± 3.63 (n = 77) | 102.90 ± 2.64 (n = 140) | 86.35 ± 3.98 (n = 63) | 4.3 × 10−3 | 0.0972 (suggestive) |
| D7Mit67 | 113.18 ± 3.58 (n = 79) | 101.54 ± 2.69 (n = 132) | 85.39 ± 3.53 (n = 77) | 4.25 × 10−4 | 0.0116 | ||
| Females | D7Mit282 | 103.20 ± 4.92 (n = 45) | 93.89 ± 3.63 (n = 80) | 81.06 ± 6.57 (n = 25) | 0.1012 | NS | |
| D7Mit67 | 110.14 ± 4.62 (n = 46) | 91.70 ± 3.62 (n = 71) | 76.65 ± 5.44 (n = 32) | 1.8 × 10−3 | 0.0458 | ||
| Males | D7Mit282 | 109.67 ± 5.18 (n = 32) | 112.75 ± 3.79 (n = 60) | 98.87 ± 4.76 (n = 38) | 0.0895 | NS | |
| D7Mit67 | 113.89 ± 5.39 (n = 33) | 112.31 ± 3.84 (n = 61) | 99.95 ± 4.45 (n = 45) | 0.172 | NS | ||
Mean and SE values were obtained by analysis of variance. Lesion size (mm2) exhibited normal distribution without transformation. C and S indicate the presence of BALB/c and STS allele, respectively; n indicates number of mice. The values for Lmr5 were calculated by analysis of covariance from all five time points (from 4 to 8 weeks of infection) as described in Materials and methods; the values for Lmr21 by analysis of variance for week 8.