Table 5.
Loci controlling IgE level in L. major infected F2 hybrids between CcS-11 and BALB/c
| Locus | Group | Marker | Genotype | P value | Corrected P value | Percent of explained variance | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CS | SS | |||||||||
| Lmr20 | Both sexes | D1Mit403 | 21.63 | 5.39 ± 0.20 (n = 69) | 16.86 | 4.75 ± 0.13 (n = 157) | 12.69 | 4.05 ± 0.20 (n = 69) | 4.35 × 10−5 | 3.07 × 10−3 | 6.09 |
| Females | D1Mit403 | 19.87 | 5.17 ± 0.25 (n = 39) | 13.25 | 4.15 ± 0.18 (n = 73) | 10.00 | 3.49 ± 0.24 (n = 41) | 2.36 × 10−5 | 1.81 × 10−3 | 11.76 | |
| Males | D1Mit403 | 18.54 | 4.99 ± 0.33 (n = 30) | 17.44 | 4.83 ± 0.20 (n = 84) | 13.86 | 4.26 ± 0.34 (n = 28) | 0.235 | NS | – | |
| Lmr5 | Both sexes | D10Mit12 | 18.03 | 4.92 ± 0.22 (n = 62) | 16.19 | 4.65 ± 0.14 (n = 150) | 11.82 | 3.88 ± 0.19 (n = 81) | 5.58 × 10−4 | 3.02 × 10−2 | 4.70 |
| Females | D10Mit12 | 17.25 | 4.81 ± 0.28 (n = 33) | 13.90 | 4.27 ± 0.19 (n = 70) | 11.49 | 3.81 ± 0.24 (n = 47) | 2.98 × 10−2 | NS | – | |
| Males | D10Mit12 | 18.38 | 4.97 ± 0.33 (n = 29) | 18.78 | 5.02 ± 0.20 (n = 80) | 11.92 | 3.90 ± 0.30 (n = 34) | 8.64 × 10−3 | NS | – | |
Mean and SE values were obtained by analysis of variance. In order to obtain normal distribution required for analysis of variance value of IgE in serum (μg/ml) was transformed by natural logarithm of value to the power of 1.5. The numbers in bold give the average non-transformed values. C and S indicate the presence of BALB/c and STS allele, respectively; n indicates number of mice.