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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Br J Haematol. 2008 Apr 13;142(2):179–191. doi: 10.1111/j.1365-2141.2008.07143.x

Figure 3. Schema for Phase III idiotype vaccine clinical trials.

Figure 3

In all three Phase III clinical trials, the patients initially undergo a biopsy to obtain tissue for vaccine production. Patients then receive induction therapy and are randomized in a 2:1 or 1:1 manner in favour of the experimental arm. The similarities and differences between the three trials are shown. NCI – National Cancer Institute; q 3w – every 3 weeks; FNA – fine needle aspiration; PD – progressive disease; DFS – disease-free survival; PFS – progression-free survival; TTP – time to progression.