Table 1.

Dice similarity index obtained from IBSR datasets on six anatomical structures: cerebellum, hippocampus, putamen, caudate, lateral ventricle, and thalamus using (a) B spline, (b) ITK demons and (c) our method. The P values were obtained by two tailed paired t-test. The P value was obtained by comparing our method with the better of the B spline and ITK demons algorithms.

Anatomic Structures	B spline based FFD	ITK demons	Proposed method	P values
Cerebellum	0.929±0.052	0.900±0.052	0.947±0.010	0.0001
Hippocampus	0.680±0.072	0.676±0.072	0.743±0.032	0.00007
Putamen	0.783±0.027	0.792±0.027	0.828±0.014	0.000001
Caudate	0.717±0.049	0.766±0.049	0.778±0.035	0.06
Lateral Ventricles	0.774±0.067	0.788±0.067	0.827±0.047	0.0037
Thalamus	0.822±0.022	0.840±0.022	0.854±0.019	0.0019