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. Author manuscript; available in PMC: 2009 Sep 16.
Published in final edited form as: J Med Chem. 2009 Jun 25;52(12):3652–3665. doi: 10.1021/jm8015798

Scheme 7a.

Scheme 7a

a Reagents and conditions: (i) (a) NaBH4, THF, rt, 3 d (b) H+. (ii) HBr/EtOH, rt, 3 d. (iii) NaH, THF, rt, 1 d. (iv) (a) 1 M NaOH, H2O-Dx, 60 °C, 5 h; (b) TFA/CH2Cl2/thioanisole, rt, 0.5 h.