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. Author manuscript; available in PMC: 2009 Sep 16.
Published in final edited form as: J Med Chem. 2009 Jun 25;52(12):3652–3665. doi: 10.1021/jm8015798

Figure 1.

Figure 1

Isothermal titration of inhibitor 21 with BHMT. Titration was performed at 25 °C in 50 mM HEPES/NaOH, pH 7.5, containing 5 mM 2-mercaptoethanol. Upper graph: experimental data. Lower graph: fit (line) to the integrated heats (full circles) from each injection of compound 21, corrected for the heat of dilution of this inhibitor. For details, see Experimental Section.