Figure 1. KerV acts as a virulence determinant in P. aeruginosa against a range of eukaryotic hosts.

(A) Bacteria quantities recovered from infected plant leaves. (B) Fly survival kinetics in a pricking infection model. Dotted lines are color-coded and represent survival medians for corresponding strains. (C) Amoeba phagocytosis of P. aeruginosa. The graphic was produced from representative experimental observations. For detailed data see Table S1. Green square, bacterial lawn; green-filled circle, no phagocytosis of bacteria; white-filled circle, clear zone due to phagocytosis of bacteria. From left to right the numbers of laid Dictyostelium were 2.0×10⁵, 8.0×10⁴, 3.2×10⁴, 1.3×10⁴, 5.1×10³, 2.0×10³, 8.2×10², 3.3×10² and 1.3×10². (D) Mouse survival kinetics in an acute lung infection model. (E and F) Histology of the infected neonatal mice lungs by PA14 (E) and P.a.-kerV (F) in the acute lung infection model. a-alveoli.