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. 2009 Sep 25;4(9):e7204. doi: 10.1371/journal.pone.0007204

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Crémieux et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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2A - Serial magnetic resonance imaging (MRI) of a rabbit infected with a low inoculum of LAC (PVL+); the mean tibial bacterial count was 4.64 Log10 CFU/g of bone on D28. The infection appears as a marrow hypersignal on D7, that becomes more intense and extends to the entire diaphysis on days 14 and 21. A medullary abscess was found at autopsy on D28. 2B - Serial MRI of a rabbit challenged with a low inoculum of LACΔpvl (PVL−). An intramedullary abscess was visible in the metaphysis and proximal diaphysis on D7, appearing as an intense marrow hypersignal. Central necrosis was noted on images obtained on D14 and D21. Bone marrow necrosis was observed macroscopically on D28. The mean tibial bacterial count on D28 was 6.08 Log10 CFU/g of bone.