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. 2009 Sep 25;4(9):e7204. doi: 10.1371/journal.pone.0007204

Figure 4. Typical radiological and histological findings after challenge with a high inoculum of LAC (PVL+).

Figure 4

A, B, C: Radiological and histological findings 28 days after challenge with a high inoculum of LAC (PVL+). Note the major deformation and widening of the entire diaphysis, compared to the control animal injected with sclerosing agent alone. Histological studies showed an intramedullary abscess and signs of chronic osteomyelitis. B: Bone abscess: the bone marrow space is filled with altered neutrophilic PMN, accompanying bone destruction and necrosis. C: Sequestrum: area of necrotic bone surrounded by an acute inflammatory exudate (pus). D, E, F: 28 days after challenge with a high inoculum of LAC (PVL+), note the soft tissue abscess surrounded by a fibrous layer on MRI and histological studies. G, H, I: Histological findings in a rabbit (PVL+) that died on D8 after challenged with a high inoculum of LAC. Histological sections (H) show muscle involvement with diffuse necrosis and dystrophic calcification, and (I) a purulent exudate in the joint cavity.