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. Author manuscript; available in PMC: 2009 Sep 16.
Published in final edited form as: Magn Reson Med. 2004 Dec;52(6):1263–1271. doi: 10.1002/mrm.20266

Figure 5. Three- way correlation in a 26 month AD mouse.

Figure 5

Panels A, C, and E are full FOV and panels B, D, and F illustrate a magnified sub-sampled area centered on the hippocampus, of the parent image to its left. The numbered arrows point to identical spatial coordinate positions in the common space of the three spatially registered volumes (in vivo, ex vivo, histological) using a linked cursor system. Spatially matched in vivo (A,B), ex vivo (C,D), and histological sections (E,F) conclusively demonstrate that the dark areas seen in vivo do indeed represent plaques. (E) Scale bar = 500 μm. (F) Scale bar = 200 μm. Plaque sharpness in vivo approaches, but is clearly inferior to that obtained on ex vivo MRI.