Table 1. GABA release following Glu application is probably mediated by GAT-2/3. Pharmacological profile of GABA transport in rat cerebrocortical NPMV in the presence of 100 µM NNC-711.
IC50 (µM) | |||||
GAT-1a | BGT a | GAT-2 a | GAT-3 a | Rat cerebrocortical NPMVb | |
β-alanine | 2920 | 1100 | 66 | 110 | 26±4 |
Taurine | >1000 | >1000 | 1270 | 2860 | 400±7 |
Nipecotic acid | 24 | 2350 | 113 | 159 | 28±0.5 |
Hypotaurine | 1010 | 536 | 52 | 73 | 20±0.4 |
SKF89976A | 0.64 | 7210 | 550 | 4390 | 372±9 |
Betaine | >1000 | 173 | >1000 | >1000 | >1000 |
Borden,L.A. GABA transporter heterogeneity: pharmacology and cellular localization (1996) Neurochem Int. 4: 335–356.
present study.