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. 2009 Sep 24;4(9):e7153. doi: 10.1371/journal.pone.0007153

Table 1. GABA release following Glu application is probably mediated by GAT-2/3. Pharmacological profile of GABA transport in rat cerebrocortical NPMV in the presence of 100 µM NNC-711.

IC50 (µM)
GAT-1a BGT a GAT-2 a GAT-3 a Rat cerebrocortical NPMVb
β-alanine 2920 1100 66 110 26±4
Taurine >1000 >1000 1270 2860 400±7
Nipecotic acid 24 2350 113 159 28±0.5
Hypotaurine 1010 536 52 73 20±0.4
SKF89976A 0.64 7210 550 4390 372±9
Betaine >1000 173 >1000 >1000 >1000
a

Borden,L.A. GABA transporter heterogeneity: pharmacology and cellular localization (1996) Neurochem Int. 4: 335–356.

b

present study.