Table 1.

FLTs (ns) of NIR molecular probes measured in various solvents and after intravenous administration in living mice. Data were fitted by a single exponential decay model. Standard deviations (sd) were less than 5% for in vitro measurements.

	chloroform	DCMa	DMSOb	acetone	ethanol	methanol	water	albumin	in vivo±sd
LS-288	N/Ac	N/A	1.33	1.02	1.00	0.81	0.44	1.00	1.12±0.02
LS-276	1.25	1.17	1.11	1.13	0.87	0.83	0.36	0.88	1.12±0.01
DTTCI	1.82	1.72	1.49	1.54	1.21	1.07	0.49	1.14	1.04±0.01
IR-806	1.28	1.15	1.01	1.02	0.82	0.66	0.27	0.61	0.77±0.02
LS-277	1.62	1.34	0.98	0.84	0.69	0.61	0.2	0.78	0.74±0.00
ICG	1.14	0.91	0.97	0.87	0.62	0.51	0.17	0.79	0.69±0.01
Cypate	1.01	0.94	0.87	0.8	0.57	0.46	0.2	0.62	0.63±0.00
IR-820	0.73	0.59	0.50	0.43	0.38	0.25	0.13	0.49	0.53±0.02

^aDCM, dichloromethane;

^bDMSO, dimethylsulfoxide;

^cN/A, not applicable