. Author manuscript; available in PMC: 2009 Sep 16.

Published in final edited form as: J Biomed Opt. 2008 Sep–Oct;13(5):054042. doi: 10.1117/1.2982535

Table 2.

Measured two-component FLT (τ, ns) of dyes from albumin solutions compared with FLTs in the liver region in mice after intravenous administration. Good agreement was observed between the two FLT components in vitro and in vivo. The in vitro and in vivo fractional composition of FLTs in the liver were significantly different for LS-276 and DTTCI, indicating the differences in protein-binding characteristics of the molecular probes. Standard deviations for in vitro measurements were less than 5%.

	in vitro		in vivo
Compound	τ₁ (F₁)^a	τ₂ (F₂)	τ₁ (F₁)	τ₂ (F₂)
LS-276	0.69 (55)	1.19 (42)	0.77±0.06 (14)	1.16±0.02 (86)
DTTCI	NS^b	1.14 (95)	0.34±0.03 (30)	1.12±0.02 (70)
IR-806	0.52 (60)	1.19 (38)	0.45±0.02 (62)	1.04±0.04 (38)
LS-277	0.64 (65)	1.15 (32)	0.48±0.03 (63)	0.98±0.02 (37)
Cypate	0.47 (69)	0.97 (30)	0.41±0.01 (75)	0.96±0.01 (25)
ICG	0.63 (61)	1.10 (37)	0.53±0.02 (67)	0.90±0.02 (33)
IR-820	0.41 (77)	0.91 (19)	0.41±0.02 (85)	0.92±0.02 (15)

Fractional component (%);

NS, not significant