Across increasing age groups, women and men demonstrate a marked reduction in LVEDV, out of proportion to a slight decrease in LV mass (Panels A and C). Accordingly, M/V ratio markedly increases for women and men (Panel B). Panel D summarizes these structural findings by showing age-associated changes in standardized values for LV mass, LVEDV, and M/V ratio. LVEDV (indexed to BSA) declines with age similarly across the 4 ethnic/racial groups (Panel E); the age-associated trend of greater M/V augmentation among African Americans was of only borderline statistical significance (Panel F). Values for panels A, B, and C are presented as means (95% CI).