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. 2009 Jan 21;29(3):600–609. doi: 10.1523/JNEUROSCI.3481-08.2009

Figure 5.

Figure 5.

HCN1 knock-out mice are less sensitive to hypnotic actions of ketamine. Mice were injected with incrementing concentrations of ketamine (5–30 mg/kg, i.v.) and the percentage of wild-type and HCN1 knock-out animals that failed to right themselves (LORR) was determined as a measure of hypnosis. HCN1 knock-out mice were less sensitive to hypnotic effects of ketamine, as indicated by the increased EC50 for ketamine-induced LORR (A) and the reduced duration of the LORR (B). *p < 0.05 by two-way RM-ANOVA, n = 11 and 13. The inverted triangle and diamond in A represent data from HCN1+/+ (n = 12) and HCN1−/− (n = 8) littermates obtained from heterozygote HCN1+/− mice following a backcross of HCN1 knock-outs to C57BL/6J mice.