TABLE 1.
Characteristic | Value for the following vaccine vector and construct at the indicated stage:
|
|||||||
---|---|---|---|---|---|---|---|---|
Placebo, all stages combined | MRKAd6 trigene
|
MRKAd5 trigene, stage IB | MRKAd5 trivalent, stage IB | MRKAd5+6 trigene
|
||||
IA | IIA | IIIA | IIB | IIIB | ||||
Dose (vg) | 0.5 × 109 | 0.5 × 1010 | 0.5 × 1011 | 0.5 × 1010 | 1.5 × 1010 | 1.0 × 109 | 1.0 × 1010 | |
No. of subjects | 26 | 8 | 8 | 8 | 8 | 8 | 40 | 41 |
Gender | ||||||||
No. (%) male | 10 (38) | 4 (50) | 4 (50) | 5 (62) | 4 (50) | 3 (38) | 20 (50) | 19 (49) |
No. (%) female | 16 (62) | 4 (50) | 4 (50) | 3 (38) | 4 (50) | 5 (62) | 20 (50) | 21 (51) |
Age | ||||||||
Mean | 30.1 | 36.3 | 34.6 | 37.3 | 29.9 | 31.3 | 34.8 | 33.9 |
SD | 8.8 | 7.2 | 9.9 | 7.6 | 9.3 | 11.0 | 9.5 | 9.7 |
Median | 26.5 | 37 | 40 | 37.5 | 28.5 | 26.5 | 37.5 | 31 |
Range | 20-47 | 22-46 | 20-45 | 26-45 | 20-45 | 20-49 | 19-48 | 21-50 |
No. (%) of the following race/ethnicity: | ||||||||
Asian/Pacific | 3 (12) | 0 (0) | 0 (0) | 0 (0) | 1 (13) | 0 (0) | 0 (0) | 3 (7) |
Black | 4 (15) | 1 (13) | 5 (62) | 0 (0) | 2 (25) | 2 (25) | 6 (15) | 7 (17) |
Caucasian | 18 (69) | 7 (87) | 3 (38) | 7 (87) | 4 (50) | 6 (75) | 30 (75) | 27 (66) |
Hispanic | 0 (0) | 0 (0) | 0 (0) | 1 (13) | 1 (13) | 0 (0) | 4 (10) | 2 (5) |
Other | 1 (4) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (5) |