Table 2.
Frequency of LRRK2 mutations
| Origin | Variant tested (predominant) |
sp= sporadic fam= familial |
Reference |
|---|---|---|---|
| North Africa Arabs |
G2019S G2019S |
sp 41% fam 37% sp 39% fam 36% |
[15, 17] |
| Ashkenazim | G2019S G2019S |
sp 13% fam 30% sp 10% fam 28% |
[17, 90] |
| Germany | Complete Seq (R793M) G2019S |
sp 2% fam 15% sp+ fam 0,5% |
[77, 91] |
| Portugal | G2019S | sp 4% fam 14% sp+ fam 6% |
[17, 92] |
| Italy | G2019S (6,6%) R1441C (4,3%) |
fam 10% sp 2% fam 4% |
[17, 93] |
| Spain | R1441G/G2019S G2019S |
fam 5%, sp+ fam 8% sp 3% fam 4% |
[17, 94] |
| United States |
G2019S G2019S |
1–2% fam 6–7% |
[18] |
| Russia | G2019S G2019S |
sp 0,5% fam 5,9% sp 1% fam 0% |
[17, 86] |
| Belgium | R1441C | sp+ fam 3,29% | [82] |
| Chile | G2019S | sp 3% fam 3% | [17] |
| Ireland | G2019S | sp <1% fam 3% | [17] |
| France | G2019S | sp+ fam 2,9% | [95] |
| Australia | G2019S | sp+ fam 1,5% | [96] |
| Brazil | G2019S | sp+ fam 2% | [97] |
| Norway | G2019S G2019S |
sp+ fam 2% sp 1% fam 1% |
[17, 98] |
| UK | G2019S G2019S |
fam 1,8% sp 1% fam 2% |
[9, 17] |
| Sweden | G2019S | sp 2% fam 0% | [17] |
| Japan | G2019S | sp <1% fam 2% | [17] |
| India | G2019S | sp <1% fam 0% | [17] |
| Canada | G2019S | sp+ fam 0% | [99, 100] |
| Greece | G2019S | sp+ fam 0% | [101] |
| Poland | G2019S | sp+ fam 0% | [102] |
| China | G2385R, risk factor P1628R, risk factor |
sp+ fam 9% sp+ fam 3% |
[103, 104] |