Table 1.
Animal species & human | Pathological diagnosis | Immunolocalization | Antibody | References |
---|---|---|---|---|
SD rats | Ischemic reperfusion injury | S3 segments | Rabbit pAb R9 | Ichimura et al., 1998 |
SD rats | TFEC-, folic acid-, cisplatin- nephrotoxicity |
S3 segments | Rabbit pAb R9 | Ichimura et al., 2004 |
SD rats | Cisplatin-nephrotoxicity | S3 segments | Rabbit pAb R9 | Amin et al., 2004 |
Wistar rats | Protein-overload nephrotoxicity | Proximal tubular cells of outer medulla |
Rabbit pAb R9 | van Timmerren et al., 2006 |
SD rats | Cisplatin-nephrotoxicity | S3 segments | Mouse mAb MARKE- 1, -2, -Trap |
Vaidya et al., 2006 |
Ren2 rats | Tubulointerstitial fibrosis | Proximal tubular epithelial cells of cortex |
Rabbit pAb R9 | de Borst et al., 2007 |
PKD2 WS25/-mice | Polycystic kidney disease | Cyst-lining epithelium derived from proximal tubules and CD |
Mouse pAb R9 | Kuehn et al., 2002 |
Human | Acute tubular necrosis | S1/S2 segments | mAb AKG7 | Han et al., 2002 |
Human | Acute tubular injury in human renal transplants |
Proximal tubules | mAb AKG7 | Zhang et al., 2008 |
Human | Acute tubular necrosis adjacent to cancer |
Proximal tubules | mAb ABE3 | Lin et al., 2007 |
Human | Fibrosis and inflammation | Proximal tubules | mAb AKG7 | van Timmerren et al., 2007 |
pAb R9 = rabbit anti-rat Kim-1 R9 pAb; mAb ABE3, or AKG7 = anti-human hKim-1 mAb; mAb MARKE-1, -2, -Trap = mouse anti-rat Kim-1 ectodomain (MARKE) mAbs.