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. Author manuscript; available in PMC: 2009 Sep 16.
Published in final edited form as: Toxicol Pathol. 2008 Apr 25;36(3):397–409. doi: 10.1177/0192623308315832

Table 1.

Immunolocalization of kidney injury molecule-1 in the kidney of rats, mice, and humans.

Animal species & human Pathological diagnosis Immunolocalization Antibody References
SD rats Ischemic reperfusion injury S3 segments Rabbit pAb R9 Ichimura et al., 1998
SD rats TFEC-, folic acid-, cisplatin-
 nephrotoxicity
S3 segments Rabbit pAb R9 Ichimura et al., 2004
SD rats Cisplatin-nephrotoxicity S3 segments Rabbit pAb R9 Amin et al., 2004
Wistar rats Protein-overload nephrotoxicity Proximal tubular cells of
 outer medulla
Rabbit pAb R9 van Timmerren et al., 2006
SD rats Cisplatin-nephrotoxicity S3 segments Mouse mAb MARKE-
 1, -2, -Trap
Vaidya et al., 2006
Ren2 rats Tubulointerstitial fibrosis Proximal tubular epithelial
 cells of cortex
Rabbit pAb R9 de Borst et al., 2007
PKD2 WS25/-mice Polycystic kidney disease Cyst-lining epithelium derived
 from proximal tubules and CD
Mouse pAb R9 Kuehn et al., 2002
Human Acute tubular necrosis S1/S2 segments mAb AKG7 Han et al., 2002
Human Acute tubular injury in human
 renal transplants
Proximal tubules mAb AKG7 Zhang et al., 2008
Human Acute tubular necrosis adjacent
 to cancer
Proximal tubules mAb ABE3 Lin et al., 2007
Human Fibrosis and inflammation Proximal tubules mAb AKG7 van Timmerren et al., 2007

pAb R9 = rabbit anti-rat Kim-1 R9 pAb; mAb ABE3, or AKG7 = anti-human hKim-1 mAb; mAb MARKE-1, -2, -Trap = mouse anti-rat Kim-1 ectodomain (MARKE) mAbs.