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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: J Neurochem. 2009 May 29;110(3):990–1004. doi: 10.1111/j.1471-4159.2009.06194.x

Table 1.

Incidence of glutamate-induced DCD in the presence of calpain or NCX inhibitors relative to same-day controls

Treatment % O2 of culture % DCD at 20 min % DCD at 60 min # of cells # of view fields
calpeptin (10 μM) 3 109.9 ± 6.7* 115 ± 6.4* 705 27
PD150606 (10 μM) 3 68.2 ± 14.0 83.1 ± 8.4 384 6
PD150606 (50 μM) 3 11.8 ± 4.8* 44.7 ± 11.8* 300 6
KB-R7943 (10 μM) 3 31.4 ± 10.7* 57.6 ± 11.7* 348 6
calpeptin (10 μM) 20 125.7 ± 10.6* 112.2 ± 4.3* 590 18
PD150606 (10 μM) 20 71.8 ± 7.1* 92.0 ± 6.2 303 6
PD150606 (50 μM) 20 17.0 ± 3.4* 41.0 ± 6.1* 302 5
KB-R7943 (10 μM) 20 56.1 ± 9.4* 77.8 ± 10.9 312 6

Nifedipine (1 μM) was present in experiments with KB-R7943 to exclude the possibility that action was due to effects on voltage-dependent Ca2+ channels. Significance was determined by comparing the relative incidence of DCD in n view fields to 100% using a two-tailed Student's t-test.

*

p<0.05