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. Author manuscript; available in PMC: 2009 Oct 11.
Published in final edited form as: J Med Chem. 2009 Jun 11;52(11):3539–3547. doi: 10.1021/jm900116d

Figure 5. Inhibitory potency does not correlate with cyanine aggregation propensity.

Figure 5

When dissolved in methanol at 5 μM concentration, compounds 11 (a), 12 (b), and 8 (c) yield simple spectra (dotted lines) consistent with monomeric structure (M). In assembly buffer (solid lines), increasing concentrations of compounds 11 and 12, but not 8, revealed the presence of both monomeric (M) and aggregated (D) species, with the latter more pronounced at high concentrations. These data suggest that 11 and 12, but not 8, underwent aggregation in aqueous solution at the concentrations tested.