Table 2.
HPV16 and HPV18 DNA load between women with and without concurrent coinfection of the same species types, stratified by cervical cytology
| Log10 HPV16 E7 copies per 1 nanogram of cellular DNA in women | Log10 HPV18 E7 copies per 1 nanogram of cellular DNA in women | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cervical cytology* | without other A9 species types | with other A9 species types | without other A7 species types | with other A7 species types | ||||||
| No. | Mean (SD) | No. | Mean (SD) | P-value† | No. | Mean (SD) | No. | Mean (SD) | P-value† | |
| All diagnoses | 559 | 2.89 (±1.33) | 243 | 2.55 (±1.33) | <0.001 | 226 | 4.03 (±1.63) | 77 | 3.40 (±1.68) | 0.001 |
| Normal | 110 | 1.86 (±1.32) | 40 | 1.50 (±1.19) | 0.11 | 43 | 3.08 (±1.48) | 13 | 1.88 (±2.15) | 0.01 |
| ASC-US | 162 | 2.79 (±1.17) | 71 | 2.54 (±1.39) | 0.16 | 63 | 3.90 (±1.60) | 19 | 3.77 (±0.98) | 0.86 |
| LSIL | 175 | 3.27 (±1.26) | 87 | 2.78 (±1.23) | 0.002 | 88 | 4.39 (±1.55) | 39 | 3.76 (±1.63) | 0.04 |
| HSIL | 107 | 3.52 (±0.99) | 45 | 3.08 (±1.06) | 0.05 | 28 | 4.77 (±1.52) | 6 | 3.19 (±0.38) | 0.03 |
*
Five women were excluded from cytology-stratified analyses because their enrollment samples were inadequate for cytologic evaluation.
†
Adjusted for current smoking status for cytology-stratified analyses and cytologic diagnoses and current smoking status for cytology-combined analyses