Table 1.
Kinetochore associating proteins in C. elegans
| C. elegans protein (gene name) |
Human homolog |
Notable domain | Reference # | |
|---|---|---|---|---|
| Kinetochore specificity |
HCP-3 (F58A4.3) |
CENP-A | Histone H3 variant | (6, 10, 17- 19) |
| HCP-4 (T03F1.9) |
CENP-C | Consensus: VRR[S/T]XR[T/I/V]R[L/V] KPLEYWRGER[I/V/P]XY |
(8, 10, 17) | |
| KNL-2 (K06A5.4) |
c14orf106 | Myb domain | (13) | |
| Microtubule interface at the outer kinetochore |
KNL-1 (C02F5.1) |
BLINKIN | [S/G]ILK motif RRSVF motif MELT repeats Coiled coil |
(17, 27) |
| KNL-3 (T10B5.6) |
(27) | |||
| MIS-12 (Y47G6A.24) |
MIS12 | (27) | ||
| KBP-1 (R13F6.1) |
(27) | |||
| KBP-2 (F26F4.13) |
(27) | |||
| NDC-80 (W01B6.9.1) |
HEC1 | (17, 27) | ||
| HIM-10 (R12B2.4) |
NUF2 | N-terminal conserved domain (Nuf2 family protein) |
(2) | |
| KBP-3 (F26H11.1) |
SPC25 | (27) | ||
| KBP-4 (Y92C3B.1) |
SPC24 | (27) | ||
| Other outer kinetochore components |
KBP-5 (C34B2.2) |
(27) | ||
| HCP-1 (ZK1055.1) |
CENP-F | Coiled coil Repeated motif conserved between HCP-1 and CENP- F (not present in HCP-2) |
(7, 17, 18, 37) |
|
| HCP-2 (T06E4.1) |
CENP-F | Coiled Coil | (7, 17, 18, 37) |
|
| CLS-2 (R107.6) |
CLASP | CLIP associating | (37) | |
| KLP-7 (K11D9.1) |
MCAK | Kinesin moter domain | (10, 18) | |
| LIS-1 (T03F6.5) |
LIS1 | WD40 repeat | (43) | |
| MEL-28 (C38D4.3) |
AHCTF1 | AT-hook-containing | (45, 46) | |
| Spindle assembly Checkpoint |
BUB-1 (R06C7.8) |
BUB1 | Kinase | (10, 17, 18) |
| BUB-3 (Y54G9A.6) |
BUB3 | WD40 repeat | (38, 39) | |
| MDF-1 (C50F4.11) |
MAD1 | Coiled coil | (18, 84) | |
| MDF-2 (Y69A2AR.30) |
MAD2 | HORMA domain | (18, 84) | |
| SAN-1 (ZC328.4) |
BUBR1/Mad3 | (24, 92, 93) | ||
| RZZ complex | CZW-1 (F20D12.4) |
ZW10 | (88, 97) | |
| ROD-1 (F55G1.4) |
ROD | (88, 97) | ||
| ZWL-1 (Y39G10AR.2) |
ZWILCH | |||
| APC actovator |
FZY-1 (ZK177.6) |
CDC20 | WD40 repeats | (114) |
| Condensin II | SMC-4 (F35G12.8) |
SMC4 | SMC domain | (52, 53) |
| HCP-6 (Y110A7A.1) |
CAP-D3 | HEAT motif | (9, 52, 53) | |
| MIX-1 (M106.1) |
SMC2 | SMC domain | (52, 53) |