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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Jul 10;19(17):5128–5131. doi: 10.1016/j.bmcl.2009.07.029

Scheme 1.

Scheme 1

Design and synthesis of fumagillin analogs. Reagents and conditions: (a) NaOH, MeOH, H2O, 0 °C; (b) DSC or 4-NO2 phenylchloroformate, TEA, CH3CN, 25 °C; (c) X, DIEA, CH3CN or EtOH, 25 °C.