Table 1. Oligomer sequences.
| oligomer | sequence | cMO |
|---|---|---|
| ntla MOa | GACTTGAGGCAGACATATTTCCGAT | 8a-h, 8a′, 8e′ 22a-b |
| heg MOa | GTAATCGTACTTGCAGCAGGTGACA | 9a-c |
| flh MOa | GGGAATCTGCATGGCGTCTGTTTAG | 10 |
| etv2 MOa | CACTGAGTCCTTATTTCACTATATC | 11 |
| spt MOa | GCTTGAGGTCTCTGATAGCCTGCAT | 12 |
| ntla 10-mer | TATGTCTGCC | 8a, 8a′ |
| “Staggered”b | ||
| ntla 12-mer | TATGTCTGCCTC | 8b |
| “Staggered”b | ||
| ntla 14-mer | TATGTCTGCCTCAA | 8c |
| “Staggered”b | ||
| ntla 16-mer | TATGTCTGCCTCAAGT | 8d |
| “Staggered”b | ||
| ntla 10-mer | GCCTCAAGTC | 8e, 8e′ |
| “Blunt”b | ||
| ntla 12-mer | CTGCCTCAAGTC | 8f |
| “Blunt”b | ||
| ntla 14-mer | GTCTGCCTCAAGTC | 8g |
| “Blunt”b | ||
| ntla 16-mer | ATGTCTGCCTCAAGTC | 8h |
| “Blunt”b | ||
| heg 13-mer | CAAGTACGATTAC | 9a |
| “Blunt”b | ||
| heg 11-mer | GCTGCAAGTAC | 9b |
| “Staggered”b | ||
| heg 10-mer | GTACGATTAC | 9c |
| “Blunt”b | ||
| flh 10-mer | GCAGATTCCC | 10 |
| “Blunt”b | ||
| etv2 10-mer | GGACTCAGTG | 11 |
| “Blunt”b | ||
| spt 10-mer | GACCTCAAGC | 12 |
| “Blunt”b | ||
| ntla RNAc | ATCGGAAATATGTCTGCCTCAAGTC | - |
| flh RNAc | CTAAACAGACGCCATGCAGATTCCC | - |
| heg RNAc | TGTCACCTGCTGCAAGTACGATTAC | - |
| etv2 RNAc | GATATAGTGAAATAAGGACTCAGTG | - |
| spt RNAc | ATGCAGGCTATCAGAGACCTCAAGC | - |
a
MO oligomers for translational inhibition of targeted mRNA.
b
Inhibitory MO oligomers for modulating cMO activity.
c
RNA oligomers for thermal denaturation studies.