Table 1. Intravenous Anesthetic Agents and Sleep-Related Neurotransmitters.

The matrix summarizes the total number of peer reviewed publications obtained from a PubMed search spanning from 1997 to 2007, in which the title listed both the intravenous (I.V.) agent (rows) and the endogenous neurotransmitter molecule (columns). The first column lists the five I.V. agents and columns 2 through 6 list the neurotransmitters studied. Monoamines include serotonin, norepinephrine, dopamine, and histamine. Column 7 summarizes the total number of citations for each I.V. agent.

I.V. Anesthetics	Monoamines	GABA	Glutamate	Acetylcholine	Adenosine	Total
Propofol	12	7	6	4	6	35
Ketamine	13	4	5	11	1	34
Pentobarbital	4	8	2	1	2	17
Midazolam	2	4	4	1	2	13
Etomidate	1	6	1	1	0	9
Total	32	29	18	18	11	108