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. Author manuscript; available in PMC: 2009 Sep 16.
Published in final edited form as: Methods. 2007 Nov;43(3):168–175. doi: 10.1016/j.ymeth.2007.06.009

Figure 2. Secretion of Hsp70 through the endolysosome pathway.

Figure 2

Our experiments suggest that hsp70 secretion involves the entry of Hsp70 into endolysosomes through ABC family transporters, where they co-localize with intravesicular cathepsin D. These organelles then are transported to the cell surface. Subsequent fusion of Hsp70 containing endolysosomes with the cell surface results in the localization of LAMP1 in the plasma membrane and release of Hsp70 along with other proteins such as cathepsin D.