Table 1.
Chronic aminoguanidine for 14 days during normal salt (NS) or high salt (HS) intake
| Group | BP (mm Hg) |
RVR (mm Hg/ mL/min) |
GFR (mL/min) |
UNaV (μeq/min) |
FENa+ (%) |
Hct (Vol%) |
BW (g) |
Plasma Volume (mL) |
|---|---|---|---|---|---|---|---|---|
| 1 | ||||||||
| 0 | 120 ± 2 | 5.4 ± 0.2 | 3.2 ± 0.1 | 2.0 ± 0.4 | 0.48 ± 0.10 | 43 ± 1 | 381 ± 6 | ND |
| 7 | 116 ± 2 | 5.3 ± 0.2 | 3.2 ± 0.2 | 1.3 ± 0.2 | 0.29 ± 0.05 | 43 ± 1 | 376 ± 9 | ND |
| +AG 14 | 116 ± 1 | 5.0 ± 0.3 | 3.0 ± 0.1 | 0.8 ± 0.1* | 0.21 ± 0.02* | 43 ± 1 | 372 ± 11 | ND |
| 2 | ||||||||
| 0 | 120 ± 1 | 5.4 ± 0.4 | 2.8 ± 0.1 | 1.3 ± 0.2 | 0.34 ± 0.05 | 43 ± 1 | 366 ± 8 | 15.7 ± 0.4 |
| 7 | 120 ± 2 | 6.1 ± 0.5 | 2.8 ± 0.2 | 3.5 ± 0.3* | 0.94 ± 0.12* | 43 ± 1 | 369 ± 8 | 15.7 ± 0.4 |
| 14 | 121 ± 1 | 5.5 ± 0.5 | 2.8 ± 0.2 | 3.5 ± 0.6* | 0.93 ± 0.14* | 44 ± 1 | 371 ± 8 | 15.9 ± 0.4 |
| 3 | ||||||||
| 0 | 121 ± 1 | 5.5 ± 0.7 | 3.1 ± 0.2 | 1.5 ± 0.2 | 0.36 ± 0.06 | 43 ± 1 | 384 ± 16 | 16.5 ± 0.7 |
| 7 | 114 ± 3* | 5.6 ± 0.4 | 2.8 ± 0.3 | 4.8 ± 0.7† | 1.26 ± 0.13* | 41 ± 1 | 382 ± 13 | 16.4 ± 0.6 |
| 14 | 115 ± 3*† | 5.4 ± 0.1 | 3.0 ± 0.3 | 4.3 ± 0.8* | 1.04 ± 0.11* | 42 ± 1 | 392 ± 14 | 16.9 ± 0.6 |
BP = blood pressure; RVR = renal vascular resistance; GFR = glomerular filtration rate; UNaV = excretion of sodium; FENa = fractional excretion of sodium; Hct = hematocrit; BW = body weight; ND = not determined; AG = aminoguanidine.
Group 1, NS + AG; group 2, HS; group 3, HS + AG.
*
Differences v day 0 within a group.
†
Difference between HS groups at a given time.