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Treatment with celecoxib led to a significant increase in urinary LTE4 levels among subjects with high baseline PGE-M levels. For individuals with high PGE-M, the median (range) magnitude of change induced by celecoxib was 34 pg/mg Cr (-208, 4673), p=0.03. For individuals with low PGE-M, the median (range) magnitude of change induced by celecoxib was -8 pg/mg Cr (-244, 229), p=0.96.
